CONOLIDINE ALKALOID FOR CHRONIC PAIN NO FURTHER A MYSTERY

Most recently, it has been discovered that conolidine and the above mentioned derivatives act around the atypical chemokine receptor 3 (ACKR3. Expressed in very similar areas as classical opioid receptors, it binds to the big selection of endogenous opioids. As opposed to most opioid receptors, this receptor functions as a scavenger and doesn't act